PHARMACOPHORIC EVALUATION OF 5-HT2A AND 5-HT2B SEROTONIN RECPEPTORS

P Hemanth - 2021 - scholarscompass.vcu.edu
… at 5-HT2B receptors, a series of DOX analogues was analyzed … structure-activity relationships
of risperidone antagonism at … 5-HT1D, 5-HT2A, 5-HT2C, and sigma-1 receptors.Fen clearly …

Exploring Off-Target Drug Activities at the Understudied Serotonin Receptors 5-HT1e and 5-HT1F

A Parpounas - 2023 - search.proquest.com
… Through structure activity relationship studies (SAR), I aim to elucidate the … Cyproheptadine
… antagonism of histamine and serotonin at receptor subtypes H1, H2 and 5HT2A, 2C and 7. …

Pharmacology and Toxicology of N-Benzylphenethylamine (“NBOMe”) Hallucinogens

AL Halberstadt - … of New Psychoactive Substances (NPS) The Science …, 2017 - Springer
… This chapter reviews the structureactivity relationships, … and colleagues synthesized a series
of rigid analogues of 25B-… , necessitating treatment with cyproheptadine. His CK level was …

[HTML][HTML] The combination of marketed antagonists of α1b-Adrenergic and 5-HT2A receptors inhibits behavioral sensitization and preference to alcohol in mice: a …

F Trovero, S David, P Bernard, A Puech, JC Bizot… - PLoS …, 2016 - journals.plos.org
… We show that the association of ifenprodil (1 mg/kg) and … that combined prazosin and
cyproheptadine could be efficient … the last enzymatic step in the synthesis of noradrenaline. Finally, …

Pharmacology of drugs used as stimulants

JR Docherty, HA Alsufyani - The Journal of Clinical …, 2021 - Wiley Online Library
… and be linked to stimulation of the 5-HT2A receptor.Amphetamine, … blockade, has high affinity
for 5-HT2C receptors.Both the … tions of fenfluramine involve 5-HT2B receptors, and MDMA …

Blockade of 5‐HT2 receptors suppresses motor unit firing and estimates of persistent inward currents during voluntary muscle contraction in humans

BI Goodlich, A Del Vecchio, SA Horan… - The Journal of …, 2023 - Wiley Online Library
Cyproheptadine binds with high affinity to 5-HT2A/B/C receptors (Boess & Martin, 1994; …
Across the full range of contraction intensities, there were no significant differences between …

Effect of Hallucinogens on Unconditioned Behavior.

M Geyer, A Halberstadt - 2018 - escholarship.org
… insights into the structureactivity relationships of hallucinogens and … at serotonin 5-HT2A,
5-HT2B and 5-HT2C-VSV receptors … with a series of phenethylamine analogues. ACS Chem …

Blockade of 5-HT2 receptors suppresses rate of torque development and motor unit discharge rate during rapid contractions

BI Goodlich, SA Horan… - Journal of …, 2022 - journals.physiology.org
… , where cyproheptadine binds with high affinity to A, B, and C, 5-HT 2 receptor subtypes (16, …
The similar length in regression lines indicates that the range of motor unit discharges were …

Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3β to suppress mTOR and β-catenin signaling pathways

HY Hsieh, CH Shen, RI Lin, YM Feng, SY Huang… - Cancer letters, 2016 - Elsevier
cyproheptadine has been previously shown to be the antagonist of the serotonin receptors
5-HT2A and 5-HT2C … Statistical significances were observed in the CPH treated group when …

The risk of chronic psychedelic and MDMA microdosing for valvular heart disease

M Tagen, D Mantuani, L van Heerden… - Journal of …, 2023 - journals.sagepub.com
… indicates the binding affinity of the ligand for the receptor. If a … LSD is a semi-synthetic
psychedelic derived from ergot alkaloids … The range of microdoses for mescaline has not been …